Mpox (monkeypox) is a zoonotic disease caused by monkeypox virus, which belongs to the orthopoxvirus genus. Concern has recently been expressed over the appearance of the human monkeypox virus and its severe clinical presentation that resembles smallpox. Currently, due to the decrescence of immunity among smallpox-vaccinated residents, and the accumulation of unvaccinated cohorts, people are generally susceptible to mpox. A cumulative number of 79411 laboratory-confirmed cases of mpox and 50 fatalities have been reported to the World Health Organization from 110 countries between 1 January and 13 November 2022. This paper provides an overview of the epidemiology and clinical features of mpox, and control and prevention approaches for mpox to fully understand and prevent human infections.