COVID–19 breakthrough infection after four doses of the vaccines: A case report

Hongrang Zhou; Guifu Li; Xiaoming Wang; Zhe Zhou; Wen Kong; Jingfei Hu; Kaiyou Ye; Wenjiang Zhong; Xiaoling Wang; Ning Xiao

doi:10.4103/2773-0344.374229

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CASE REPORT

Year : 2023 \| Volume : 3 \| Issue : 1 \| Page : 7

COVID–19 breakthrough infection after four doses of the vaccines: A case report Hongrang Zhou¹, Guifu Li¹, Xiaoming Wang², Zhe Zhou¹, Wen Kong¹, Jingfei Hu¹, Kaiyou Ye¹, Wenjiang Zhong¹, Xiaoling Wang³, Ning Xiao⁴ ¹ Qingpu District Center for Disease Control and Prevention, Shanghai 201799, China ² Program in Public Health, College of Health Sciences, University of California at Irvine, Irvine 92697, USA ³ State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China ⁴ National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology; Key Laboratory of Parasitic and Vector Biology, National Health Commission of China; The School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China Correspondence Address: Hongrang Zhou Qingpu District Center for Disease Control and Prevention, Shanghai 201799 China Ning Xiao National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology; Key Laboratory of Parasitic and Vector Biology, National Health Commission of China; The School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200001 China Wenjiang Zhong Qingpu District Center for Disease Control and Prevention, Shanghai 201799 China Xiaoling Wang State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai 200433 China Source of Support: None, Conflict of Interest: None DOI: 10.4103/2773-0344.374229

The COVID-19 vaccines provide a high degree of protection against severe disease, hospitalisation, and death. However, no vaccine claimed 100% effectiveness and it is expected that a small proportion of vaccinated individuals may develop a breakthrough infection due to individual differences, virus variants and other factors. We conducted an epidemiological investigation and analysis of an imported case who had finished four doses of vaccination, and in order to provide a relevant reference for regular epidemic prevention and control in the post-pandemic era.



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